Study on Control of Blood Sugar with Different Types of Insulin in A Tertiary Care Hospital

Abstract

The main aim of study is to check optimum control of blood sugar using Human actrapid insulin and Human mixtard insulin in a range of 100-200mg/dl at tertiary care hospital. 114 patients with Type 2 Diabetes mellitus were treated with different insulin’s. The data collected is Baseline comparison of HbA1c% of two different insulin’s, Random blood sugar values at different time intervals (7AM, 1PM, 7PM) and post prandial blood sugar values were recorded to show the effective insulin among them. Oral hypoglycemic drugs were also administered to few patients. The baseline comparison of HbA1c% does not showed a significant difference at p value 0.8054. The baseline values of HbA1c% were compared with patients received HAI at p value <0.0001 showed significant reduction after treatment. Likewise baseline values of HbA1c % were compared with patients received HMI at p value <0.0001 showed reduction after treatment. The GRBS in patients received HAI at different time intervals did not show a significant difference at p value 0.1506. The GRBS in patients received HMI at different time intervals was found to be significant reduction at p value 0.0038. The follow-up data of GRBS after 3 months was also studied and showed a significant reduction of sugar levels in patients received HAI (P value0.0059) and in patients received HMI (P value -0.0028). The PPBS comparison between HMI and HAI did not show a significant difference at p value-0.1220. Human mixtard insulin showed significant effectiveness compared to Human actrapid insulin at confidence interval of 95%, hence p value of <0.05 is considered significant.