Affiliation:
1. Biochemistry Department, Crosshouse Hospital, Kilmarnock KA2 0BE,
UK
Abstract
Background: The presence of macroenzymes can cause significant diagnostic confusion and their detection can involve relatively cumbersome analytical procedures. Methods: Using a simplified polyethylene glycol precipitation technique and isoenzyme electrophoresis, this report describes the construction of reference ranges of precipitable activity for each of seven commonly measured enzymes in plasma. Results: The proposed reference ranges are reported. Since introducing the protocol, 12 cases of macroenzymaemia have been encountered. Three typical case histories are described in some detail. Conclusions: The polyethylene glycol precipitation method has thus far proved to be a simple and effective additional test for the detection of macroenzymes when the plasma enzyme activity is elevated.
Subject
Clinical Biochemistry,General Medicine
Cited by
65 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献