Author:
Panesar N S,Li C Y,Rogers M S
Abstract
Objective: To establish gestation-related reference intervals for thyroid hormones in a Chinese population. Materials and methods: A prospective study with 343 healthy pregnant women (5-41 weeks) and 63 non-pregnant controls. Thyroid stimulating hormone (TSH), free thyroxine (T4) and tri-iodothyronine (T3) (and human chorionic gonadotrophin) were measured by immunoassays. The median, 2·5th and 97·5th percentiles at 4-week intervals werecalculated. Data were also analysedfor significant trends using ANOVA. Results: Free T3 decreased during pregnancy, whereas free T4 initially increased, peaking between 9-13 weeks and then decreased, the decline becoming significant by week 21. TSH mirrored changes in free T4. Conclusion : The gestation-related reference intervals for thyroid hormones should alleviate the misinterpretation of thyroid function in pregnancy.
Subject
Clinical Biochemistry,General Medicine
Cited by
169 articles.
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