Warfarin-Resistance Genotype Determination in the Norway Rat, Rattus Norvegicus-Reference-Cited by-同舟云学术

Warfarin-Resistance Genotype Determination in the Norway Rat, Rattus Norvegicus

Published:1979-07 Issue:3 Volume:13 Page:209-214
ISSN:0023-6772
Container-title:Laboratory Animals
language:en
Short-container-title:Lab Anim

Author:

Martin A. D.¹,Steed Linda C.¹,Redfern R.¹,Gill J. E.¹,Huson L. W.¹

Affiliation:

1. Pest Infestation Control Laboratory, Ministry of Agriculture, Fisheries and Food, Hook Rise South, Tolworth, Surbiton, Surrey, KT6 7NF, United Kingdom

Abstract

Summary The 2-stage determination is based on changes in blood coagulation activity brought about both by the administration of warfarin in conjunction with vitamin K1 epoxide and by feeding a vitamin K-free diet for 4 days. When it was applied to laboratory-bred rats of known warfarin-resistance genotype, 35/35 homozygous susceptible, 44/44 homozygous resistant and 131/133 heterozygous rats were correctly classified. This method was equally effective in identifying the genotype of wild rats carrying the warfarin-resistance gene, Rw2. The procedure is rapid and accurate.

Publisher

SAGE Publications

Subject

General Veterinary,Animal Science and Zoology

Link

http://journals.sagepub.com/doi/pdf/10.1258/002367779780937852

Reference16 articles.

1. Mechanism of warfarin resistance. Warfarin and the metabolism of vitamin K1

2. Case of Apparent Resistance of Rattus norvegicus Berkenhout to Anticoagulant Poisons

3. Proceedings of the Association of Applied Biologists

4. Heritable Resistance to Warfarin in Rats

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