Volvulus at the i1eocaecal junction in germfree mice

Abstract

16 cases of intestinal volvulus were observed in a total of 200 inbred C57BL/6N, GR/N, and DBA/2N germfree mice during the course of 2 years. The volvulus was a twisting of the caecum at the junction of the ileum, caecum and colon, resulting in occlusion and death. In each case the caecum was greatly enlarged. During the same period no intestinal volvulus was seen in 5 other germfree strains or in F1 to F4 generations of identical strains of microflora-associated and conventionalized mice.