Affiliation:
1. Toxicology Laboratories, AB Astra, 15185 Södertälje, Sweden
Abstract
As incidental findings uroliths were observed in the renal pelvis of Sprague-Dawley rats in an 18-month toxicity study. Of 220 rats examined, uroliths were found in 55 (35 males and 20 females). Infrared spectral analysis of the stones indicated a content of ammonium magnesium phosphate. Formation of the uroliths may have started by mineralization of degenerating hyperplastic epithelium of the renal papilla.
Subject
General Veterinary,Animal Science and Zoology
Cited by
20 articles.
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