Periodontitis and Type 2 Diabetes: Is Oxidative Stress the Mechanistic Link?

Author:

Allen EM1,Matthews JB2,O'Connor R3,O'Halloran D4,Chapple ILC5

Affiliation:

1. Clinical Lecturer, Dept. of Restorative Dentistry, Cork University Dental School & Hospital, Cork, Ireland.

2. Reader in Oral Immunology, Birmingham Dental School & Hospital, Birmingham, UK.

3. Professor of Cell Biology, Dept. of Biochemistry, Biosciences Institution, University College Cork, Ireland.

4. Consultant Physician, Department of Endocrinology, Cork University Hospital, Cork, Ireland.

5. Professor/Hon. Consultant, Dept. of Periodontal Research, Birmingham Dental School & Hospital, Birmingham, UK.

Abstract

Periodontitis is a common, chronic inflammatory disease initiated by bacteria which has an increased prevalence and severity in patients with type 2 diabetes. Recent studies indicate that the co-morbid presence of periodontitis can, in turn, adversely affect diabetic status and the treatment of periodontitis can lead to improved metabolic control in diabetes patients. Current evidence points to a bidirectional interrelationship between diabetes and inflammatory periodontitis. The importance of oxidative stress-inflammatory pathways in the pathogenesis of type 2 diabetes and periodontitis has recently received attention. Given the bidirectional relationship between these two conditions, this review discusses the potential synergistic interactions along the oxidative stress-inflammation axis common to both type 2 diabetes and periodontitis, and the implications of this relationship for diabetic patients.

Publisher

SAGE Publications

Subject

General Medicine

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