Affiliation:
1. Kartal Kosuyolu Heart and Research Hospital, Cardiovascular Surgery Clinic, 34846 Kartal, Istanbul, Turkey
Abstract
Antibiotic treatment, surgical intervention and postoperative antibiotic regimens are recommended for the treatment of brucella endocarditis (BE). Our clinical antibiotic regimens involve a triple antibiotic regimen for treating BE before the operation. The combination of three antibiotics is continued for at least six months and until the titres of the Wright serologic test are diminished to 1:160 levels. In this study, our aim was to evaluate the effects of combined medical and surgical treatments on survival and relapse rates in the periods of mid to late terms. We investigated 13 patients who were treated between January 1993 and June 2009. Our clinical observations led us to use a combination of rifampicin (900 mg twice a day), streptomycin (12 to 16 mg/kg/24 h intramuscularly) and doxycycline (200 mg/kg twice a day); rifampicin, tetracycline (8 mg/kg three times a day) and cotrimoxazole (15 mg/kg twice a day) or rifampicin, doxycycline and cotrimoxazole regimen for treating BE before the operation. This treatment should be continued for at least six months after surgery in order to prevent relapses.
Subject
Infectious Diseases,Public Health, Environmental and Occupational Health
Cited by
2 articles.
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1. Sulfonamides and Trimethoprim;Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases;2015
2. Brucella aortitis: the missing link;International Journal of Rheumatic Diseases;2013-10