Chemical-induced chromosome damage

Author:

Dean B. J.1

Affiliation:

1. Shell Research Ltd, Tunstall Laboratory, Broad Oak Road, Sittingbourne, Kent

Abstract

The development of methods for the investigation of chemical-induced chromosome damage is described using either bone marrow cells from rats and mice, or cultured rat leucocytes. The application of these methods to 4 biologically active compounds is demonstrated, and the value of such compounds as control materials for similar investigations is discussed.

Publisher

SAGE Publications

Subject

General Veterinary,Animal Science and Zoology

Cited by 50 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens;Mutation Research/Genetic Toxicology and Environmental Mutagenesis;2008-07

2. Genotoxicity of benzene and its metabolites;Mutation Research/Reviews in Mutation Research;2004-03

3. The influence of two carotenoid food dyes on clastogenic activities of cyclophosphamide and dioxidine in mice;Food and Chemical Toxicology;1998-01

4. Generation of free oxygen radicals and clastogenesis in bone marrow cells in MRL/1 mice;Bulletin of Experimental Biology and Medicine;1997-01

5. Effect of ethanol on urethane carcinogenesis;Journal of Environmental Science and Health, Part C;1996-06

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