Affiliation:
1. Área de Farmacología, Departamento de Fisiopatología y Etiopatogenia,
Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Chorroarín 280
(1427), Buenos Aires, Argentina
Abstract
In order to perform pharmacokinetic studies involving multiple blood sampling, repeated at variable intervals of time, a simple and reliable non-surgical jugular catheterization technique was developed. Six cats were catheterized 48 times using an indwelling through-the-needle type catheter (22G and 20.3 cm) placed into the jugular vein through an over-the-needle type (20G and 32 mm). Catheters remained in place for 1–13 days (median 3 days) without loss of patency until removal. Each jugular was catheterized a range of 2–6 times, with a total indwelling time of 4–33 days. No clinical signs of phlebitis, thrombosis or sepsis were observed either during or after the studies. This technique allows an easy, non-painful, non-stressful blood withdrawal during extended sampling periods, with minimal damage of the veins.
Subject
General Veterinary,Animal Science and Zoology
Cited by
18 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献