Differential susceptibil ity to Brugia pahangi infection in Mongolian gerbils (Meriones unguiculatus) of different coat colour-Reference-Cited by-同舟云学术

Differential susceptibil ity to Brugia pahangi infection in Mongolian gerbils (Meriones unguiculatus) of different coat colour

Published:2000-07-01 Issue:3 Volume:34 Page:290-297
ISSN:0023-6772
Container-title:Laboratory Animals
language:en
Short-container-title:Lab Anim

Author:

Shimizu-Suganuma Masumi¹,Shichinohe Kazuhiro²,Tsukidate Setsuko³,Fujita Koichiro³

Affiliation:

1. Department of Laboratory Animal Science. Nippon Medical School, 1-1-5. Sendagi, Bunkyo-ku, Tokyo 113, Japan; Department of Medical Zoology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113, Japan

2. Department of Laboratory Animal Science. Nippon Medical School, 1-1-5. Sendagi, Bunkyo-ku, Tokyo 113, Japan; Department of Medical Zoology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113, Japan

3. Department of Medical Zoology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113, Japan

Abstract

The influence of intraspecific host variables on the response to parasitic infections is an important aspect of host-parasite relationships, yet little is known about this aspect of filariasis for lack of a model. This study presents coat colour mutants of the Mongolian gerbil (Meriones unguiculatus) as potential new models for research into the effects of host genetic variation on response to filarial infection. Peak level of microfilaraemia, eosinophil response, body weight and degree of splenomegaly in gerbils infected with Brugia pahangi varied with agouti, albino, and black coat colour. These results suggested that coat colour-related genes might influence host immune response to developmental stages of the parasite and eosinophil-mediated reaction might cause host damage.

Publisher

SAGE Publications

Subject

General Veterinary,Animal Science and Zoology

Link

http://journals.sagepub.com/doi/pdf/10.1258/002367700780384645

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