Genital shedding of herpes simplex virus type 2 in childbearing-aged and pregnant women living in Gabon-Reference-Cited by-同舟云学术

Genital shedding of herpes simplex virus type 2 in childbearing-aged and pregnant women living in Gabon

Published:2006-02-01 Issue:2 Volume:17 Page:124-127
ISSN:0956-4624
Container-title:International Journal of STD & AIDS
language:en
Short-container-title:Int J STD AIDS

Author:

Ozouaki Francis¹,Ndjoyi-Mbiguino Angélique²,Legoff Jérôme³,Onas Isabelle Ndombi⁴,Kendjo Eric⁵,Si-Mohamed Ali³,Mbopi-Kéou François-Xavier⁶,Malkin Jean-Elie⁷,Bélec Laurent³

Affiliation:

1. Maternité Joséphine Bongo, Gabon

2. Département de Microbiologie, Laboratoire National de Référence des Maladies Sexuellement Transmissibles et de l'infection à VIH, Faculté de Médecine, Université des Sciences de la Santé Libreville, Gabon

3. Université Paris V, Epuipe 'Immunité et Biothérapie Muqueuse', Unité INSERM Internationale U743 ('Immunologie Humaine'), Centre de Recherches Biomédicales des Cordeliers & Laboratoire de Virologie, Hôpital Européen Georges Pompidou, Paris, France

4. Service de Gynécologie et Obstétrique, Centre Hospitalier de Libreville, Gabon

5. Département de Parasitologie-Mycologie, Faculté de Médecine, Université des Sciences de la Santé, Libreville, Gabon

6. Faculté de Médecine et de Sciences Biomédicales, Université de Yaoundé I & Laboratoire de Santé Hygiène Mobile, Yaoundé, Cameroun

7. Centre Médical, Institut Pasteur, Paris, France

Abstract

The prevalence of genital shedding of herpes simplex virus (HSV)-2 and related risk factors was evaluated in a prospective population of 355 women attending the Maternity Joséphine Bongo, in Libreville, Gabon. We found a high prevalence (66%) of HSV-2 seropositivity, with a high proportion, 14%, of women harbouring HSV-2 DNA shedding in their genital secretions. HSV-2 genital shedding was positively associated with previous episodes of genital blisters, current genital ulcer, current genital blister, HIV seropositivity and HSV-2 seropositivity. The high prevalence of HSV-2 in childbearing-aged population indicates that young women living in Gabon are at high risk for HIV acquisition in HIV-seronegative women sexually exposed to HIV, for HIV transmission in HIV-infected women co-infected by HSV-2 and finally for HSV-2 vertical transmission during pregnancy.

Publisher

SAGE Publications

Subject

Infectious Diseases,Pharmacology (medical),Public Health, Environmental and Occupational Health,Dermatology

Link

http://journals.sagepub.com/doi/pdf/10.1258/095646206775455711

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The epidemiology of herpes simplex virus type 2 in sub-Saharan Africa: systematic review, meta-analyses, and meta-regressions;2021-01-26

2. HSV-2 Infection as a Potential Cofactor for HIV Disease Progression and Selection of Drug Resistance Mutations in Adults under WHO-Recommended First-Line Antiretroviral Therapy: A Multicentric, Cross-Sectional Study in Cameroon, Central African Republic, Chad, and Gabon;Tropical Medicine and Infectious Disease;2020-08-24

3. Low prevalences of HIV infection and HSV genital shedding in the general adult female population in Senegal;The Journal of Infection in Developing Countries;2015-11-30

4. Sexually Transmitted Infections;Male Genital Lesions;2012-06-15

5. Prevalence of Herpes Simplex Virus Type 2 in Different Risk Groups: Thirty Years after the Onset of HIV;Intervirology;2012