Lamivudine-associated macrocytosis in HIV-infected patients-Reference-Cited by-同舟云学术

Lamivudine-associated macrocytosis in HIV-infected patients

Published:2007-01-01 Issue:1 Volume:18 Page:39-40
ISSN:0956-4624
Container-title:International Journal of STD & AIDS
language:en
Short-container-title:Int J STD AIDS

Author:

Khawcharoenporn Thana¹,Shikuma Cecilia M²,Williams Andrew E³,Chow Dominic C⁴

Affiliation:

1. Department of Medicine, University of Hawaii, Honolulu, Hawaii

2. Department of Medicine, University of Hawaii, Honolulu, Hawaii; Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, Hawaii

3. Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, Hawaii; John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii

4. Department of Medicine, University of Hawaii, Honolulu, Hawaii; Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, Hawaii; Department of Pediatrics, University of Hawaii, Honolulu, Hawaii

Abstract

Macrocytosis has been increasingly observed in HIV-infected population and is an early indicator of bone marrow toxicity. A retrospective study was conducted among these patients in a HIV clinic to assess risk factors of macrocytosis. We found that lamivudine was strongly associated with macrocytosis (OR = 24.6 [2.9–3223.0], P = 0.001). This association may be due to lamivudine's effect on erythrocyte synthesis.

Publisher

SAGE Publications

Subject

Infectious Diseases,Pharmacology (medical),Public Health, Environmental and Occupational Health,Dermatology

Link

http://journals.sagepub.com/doi/pdf/10.1258/095646207779949934

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