Favourable outcome of progressive multifocal leukoencephalopathy with mefloquine treatment in combination with antiretroviral therapy in an HIV-infected patient-Reference-Cited by-同舟云学术

Favourable outcome of progressive multifocal leukoencephalopathy with mefloquine treatment in combination with antiretroviral therapy in an HIV-infected patient

Published:2012-08 Issue:8 Volume:23 Page:603-605
ISSN:0956-4624
Container-title:International Journal of STD & AIDS
language:en
Short-container-title:Int J STD AIDS

Author:

Adachi E¹,Koibuchi T¹,Imai K¹,Kikuchi T²,Koga M²³,Nakamura H²³,Miura T²,Iwamoto A¹²,Fujii T¹

Affiliation:

1. Department of Infectious Diseases and Applied Immunology, Research Hospital of The Institute of Medical Science

2. Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science

3. International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Abstract

A 33-year-old man who developed progressive multifocal leukoencephalopathy (PML) with HIV infection is reported. The patient exhibited rapid decline in neurological status after initiation of antiretroviral therapy (ART), which was attributed to the PML-immune re-constitution inflammatory syndrome. Following the administration of mefloquine in combination with ART, the patient's neurological status improved substantially. This case suggests that further investigation of the use of mefloquine might be warranted for treatment of PML in HIV-infected patients.

Publisher

SAGE Publications

Subject

Infectious Diseases,Pharmacology (medical),Public Health, Environmental and Occupational Health,Dermatology

Link

http://journals.sagepub.com/doi/pdf/10.1258/ijsa.2012.011305

Reference8 articles.

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