Affiliation:
1. Department of Clinical Studies–Philadelphia, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA 19104, USA
2. Dipartimento di Scienze Biomediche, Facoltà di Medicina e Chirurgia, Università degli Studi di Sassari, I 07100 Sassari, Italy
Abstract
Gabapentin has been used to treat a variety of conditions in both human and veterinary medicine, including seizures, neuropathies and chronic pain. However, little information is known about the effects of gabapentin on the minimum alveolar concentration (MAC) of volatile anaesthetics. In this study, we investigated the effect of intraperitoneal administration of gabapentin on isoflurane MAC in adult male rats and hypothesized that gabapentin would decrease MAC in a dose-dependent manner. Using a standard MAC study protocol, we compared five treatment groups (G) receiving 0 (G0), 30 (G30), 100 (G100), 300 (G300) and 1000 (G1000) mg/kg gabapentin intraperitoneally and compared post-drug MAC values among groups and with corresponding baseline MAC values determined in each group prior to drug testing. The average baseline isoflurane MAC value was 1.45 ± 0.17%, which did not differ significantly between groups (1.47 ± 0.23% [G30], 1.46 ± 0.23% [G100], 1.48 ± 0.18% [G300] and 1.42 ± 0.2% [G1000]). In the G300 and G1000 groups, the isoflurane MAC value decreased significantly by 19% and 18%, respectively, from corresponding baseline values ( P< 0.05, when compared with G0). Linear regression analysis revealed a negative correlation between blood gabapentin concentration and percent change in MAC ( R2 = 0.43; P< 0.05) but not dose. In conclusion, high-dose intraperitoneal gabapentin decreased isoflurane MAC. However, the effect was small and not dose-dependent, and is unlikely to be clinically significant.
Subject
General Veterinary,Animal Science and Zoology
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献