Clostridium difficile-associated typhlitis in specific pathogen free guineapigs in the absence of antimicrobial treatment-Reference-Cited by-同舟云学术

Clostridium difficile-associated typhlitis in specific pathogen free guineapigs in the absence of antimicrobial treatment

Published:1989-07-01 Issue:3 Volume:23 Page:203-207
ISSN:0023-6772
Container-title:Laboratory Animals
language:en
Short-container-title:Lab Anim

Author:

Boot R.¹,Angulo A. F.²,Walvoort H. C.³

Affiliation:

1. Department of Animal Supply and Laboratory for Parasitology and Mycology, National Institute of Public Health and Environmental Protection, PO Box 1,3720 BA Bilthoven, The Netherlands

2. Laboratory for Bacteriology, National Institute of Public Health and Environmental Protection, PO Box 1,3720 BA Bilthoven, The Netherlands

3. Laboratory for Pathology, National Institute of Public Health and Environmental Protection, PO Box 1,3720 BA Bilthoven, The Netherlands

Abstract

Clostridium difficile (toxin) associated typhlitis was diagnosed in untreated barrier-maintained specific pathogen free guineapigs. It resembled the pathological lesions of antibiotic induced enterocolitis. The possible role of limited colonization resistance to C. difficile provided by mouse enteric microflora in the pathogenesis of the disease is discussed.

Publisher

SAGE Publications

Subject

General Veterinary,Animal Science and Zoology

Link

http://journals.sagepub.com/doi/pdf/10.1258/002367789780810626

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