Gastrointestinal pH measurement in rats: influence of the microbial flora, diet and fasting

Author:

Ward F. W.1,Coates M. E.1

Affiliation:

1. The Robens Institute, University of Surrey, Guildford, Surrey GU2 5XH, United Kingdom

Abstract

The pH of the rat intestinal tract was decreased by the presence of a microbial flora, but its influence in the forestomach is less clear. Stomach pH values varied according to the amount of food present at the time of measurement. Fasting increased the pH of the gastrointestinal tract in conventional rats but had little effect in germfree rats. In the conventional rat, feeding a purified diet compared with a commercial diet resulted in a lower pH in the forestomach and a higher pH in the caecal contents. Magnesium trisilicate promoted gastric emptying in conventional rats and its antacid effect was observed only in the caecum and colon.

Publisher

SAGE Publications

Subject

General Veterinary,Animal Science and Zoology

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