Vascular access for extracorporeal therapy in the rabbit

Author:

Canaud B.1,Charlton B.2,Antony Jayne3,Schindhelm K.2,Moran J. E.4

Affiliation:

1. Service de Néphrologie, Hôpital Saint-Charles, Montpellier, France

2. Centre for Biomedical Engineering, University of New South Wales, Kensington, New South Wales 2033, Australia

3. Department of Medicine, University of Sydney, Sydney, Australia

4. Department of Medicine, St. Vincent's Hospital, Melbourne, New South Wales 2033, Australia

Abstract

A technique allowing short-term blood access for extracorporeal therapy in rabbits is described. The technique utilizes silicone rubber cannulae and teflon vessel tips to construct an externalized carotid-jugular arteriovenous shunt. The insertion procedure takes 1 h and extracorporeal blood flows in excess of 10 ml/min are obtainable for up to 7 days. Blood flow may still be obtained following shunt clotting by insertion of smaller diameter catheters through the arterial cannula. This technique has been successfully used for extracorporeal therapy in rabbit disease models.

Publisher

SAGE Publications

Subject

General Veterinary,Animal Science and Zoology

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