Affiliation:
1. Zentrales Tierlaboratoriun der Medizinischen Hochschule Hannover, Karl-Wiechert-Allee 9, D-3000 Hannover 61, Federal Republic of Germany
Abstract
Investigation of 18 inbred and 6 F1 hybrid mouse strains has shown that the glomerular filtration rate, bodyweight and kidney weight showed strain- and sex-dependent differences. Covariance analysis showed stronger correlations (genetic and environmental) between glomerular filtration rate and bodyweight than between glomerular filtration rate and kidney weight. This was predominantly due to a high within-strain variation of kidney weight (56%) in male mice. Therefore an allometric regression was calculated between the 48 strain means of glomerular filtration rate (GFR) and bodyweight (BW): GFR = 0·036 × BW0·74 Thus the term BW0·74 a suitable correction term for comparing the heat production of different species, is also suitable for the correction of glomerular filtration rate within one species.
Subject
General Veterinary,Animal Science and Zoology
Cited by
27 articles.
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