Ear tag induced Staphylococcus infection in mice-Reference-Cited by-同舟云学术

Ear tag induced Staphylococcus infection in mice

Published:1989-07-01 Issue:3 Volume:23 Page:229-233
ISSN:0023-6772
Container-title:Laboratory Animals
language:en
Short-container-title:Lab Anim

Author:

Cover C. E.¹,Keenan C. M.²,Bettinger G. E.³

Affiliation:

1. Haskell Laboratory for Toxicology and Industrial Medicine, E.I. du Pont de Nemours and Company, Newark, DE 19714, USA

2. Haskell Laboratory for Toxicology and Industrial Medicine, E.I. du Pont de Nemours and Company, Newark, DE 19714, USA; Department of Safety Assessment, Merck Sharp and Dohme Research Laboratories, West Point, PA 19426, USA

3. Haskell Laboratory for Toxicology and Industrial Medicine, E.I. du Pont de Nemours and Company, Newark, DE 19714, USA; Glenolden Laboratory, E.I. du Pont de Nemours and Company, Glenolden, PA 19036, USA

Abstract

Mice used in a 2-year oral toxicity study developed a progressive, moist dermatitis. The initial lesions were seen around the ears in which metal identification tags had been placed and usually progressed to include the skin of the neck and shoulder. Clinically, the mice were pruritic, lost weight, had rough coats, and became moribund. The predominant finding at necropsy was pale brown kidneys with irregular granular surfaces. Histologically, there was inflammation and focal-to-diffuse necrosis in the visceral organs and affected skin. The predominant organism isolated from the skin, kidneys and heart blood was Staphylococcus aureus. This bacterium is a common inhabitant of the skin of conventionally housed mice and its isolation from the kidneys and blood suggested that the portal of entry was the wound caused by the insertion of the metal ear tag.

Publisher

SAGE Publications

Subject

General Veterinary,Animal Science and Zoology

Link

http://journals.sagepub.com/doi/pdf/10.1258/002367789780810482

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