Induction of pregnancy-associated murine protein-1 in dwarf mice by human growth hormone

Author:

Hau J.1,Poulsen O. M.1,Hansen N. F. Dagnæs1,Worm K. R.1

Affiliation:

1. Department of Veterinary Pathology, Laboratory Animal Unit, The Royal Veterinary and Agricultural University, Copenhagen, Bulowsvej 13, 1870 Frederiksberg C, Denmark

Abstract

Pregnancy-associated murine protein-1 (PAMP-1) could not be detected in peripheral blood of female dwarf mice (genotype dw/dw of the DW strain). By contrast the normal size females of the DW strain (genotypes +/+ and +/dw) had PAMP-1 serum levels of 18·9 AU ± 15·7 AU/ml. Following administration of biosynthetic human growth hormone (hGH) every 2h for 52 h PAMP-1 was detected in all dwarf females at concentrations of 16·0 AU ± 3·3 AU/ml. The albumin levels in the circulation of DW females of normal size were significantly higher ( P<0·05) than those of DW dwarfs, and the hGH administration did not change the serum albumin levels. The present experiment adds weight to the suggestion that the PAMP-1 serum level is regulated by GH.

Publisher

SAGE Publications

Subject

General Veterinary,Animal Science and Zoology

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Animal Models;Handbook of Laboratory Animal Science, Volume II, Third Edition;2011-04-25

2. Pregnancy-associated murine protein-1 (PAMP-1) in wild rodents;Journal of Experimental Zoology;1992-12-01

3. Pregnancy-associated murine protein-1 plasma levels during oestrus cycle, pseudopregnancy and pregnancy in the mouse;Laboratory Animals;1991-04-01

4. Animal Models for Human Diseases;Sourcebook of Models for Biomedical Research

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3