Affiliation:
1. Surgical Teaching Unit, Veterinary Faculty, University of Zaragoza, Spain
2. Microbiological Teaching Unit Veterinary Faculty, University of Zaragoza, Spain
Abstract
Ketamine and medetomidine produced chemical restraint for minor procedures in mice. Male mice required 50 mg/kg ketamine, 10 mg/kg medetomidine intraperitoneally (i.p.), and females a higher dose of ketamine (75 mg/kg i.p.). The onset of restraint effects, judged by loss of righting reflex, was more rapid in males than females. The effects were reversed using atipamezole (1–2.5 mg/kg). Recovery following administration of atipamezole was more rapid in males than females. We conclude that ketamine/medetomidine, followed by reversal with atipamezole, is an effective technique for chemical restraint in the mouse.
Subject
General Veterinary,Animal Science and Zoology
Cited by
69 articles.
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