Mammary tumour induction by pituitary grafting in male mice: An animal model for male breast cancer-Reference-Cited by-同舟云学术

Mammary tumour induction by pituitary grafting in male mice: An animal model for male breast cancer

Published:1993-01-01 Issue:4 Volume:27 Page:358-363
ISSN:0023-6772
Container-title:Laboratory Animals
language:en
Short-container-title:Lab Anim

Author:

Nagasawa H.,Morii S.¹,Furuichi R.,Iwai Y.²,Iwai M.,Mori T.³,Goto Y.⁴

Affiliation:

1. The 2nd Department of Pathology, Kansai Medical University, Moriguchi 570, Japan

2. Research Institute, Osaka Prefectural University, Sakai 593, Japan

3. Zoological Institute, Faculty of Science, University of Tokyo, Tokyo 113, Japan

4. Experimental Animal Research Laboratory, Meiji University, Kawasaki 214, Japan

Abstract

Isologous anterior pituitary grafting, 4 each, to 3-4-month-old SHN and SLN male mice resulted in an appearance of mammary tumours from 8 months of age and the incidence at 12 months reached 53·8% in each strain. All tumours were diagnosed as type B adenocarcinomas. In association with the results, normal mammary gland growth and mouse mammary tumour virus (MMTV)-gp52 antigen levels in the submaxillary glands were stimulated by the treatment in these strains. The effect of pituitary grafting was much less in GR/A male mice in which no mammary tumours appeared.

Publisher

SAGE Publications

Subject

General Veterinary,Animal Science and Zoology

Link

http://journals.sagepub.com/doi/pdf/10.1258/002367793780745570

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