Changes in Hepatitis a Virus Seroepidemiology in Hiv-Infected Brazilian Patients-Reference-Cited by-同舟云学术

Changes in Hepatitis a Virus Seroepidemiology in Hiv-Infected Brazilian Patients

Published:2008-05 Issue:5 Volume:19 Page:321-326
ISSN:0956-4624
Container-title:International Journal of STD & AIDS
language:en
Short-container-title:Int J STD AIDS

Author:

Aloise R¹,De Almeida A J¹²,Sion F S²,Morais-De-SÁ C A²,Gaspar A M C¹,De Paula V S¹

Affiliation:

1. Department of Virology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro;

2. Medical Clinic B, Gaffrée & Guinle University Hospital, UNIRIO, Rio de Janeiro, Brazil

Abstract

Shifting of hepatitis A virus (HAV) epidemiology from a high towards an intermediate endemicity pattern and use of antiretroviral therapy increased the risk of HIV/HAV coinfection in developing countries. The aim of this study was to investigate the presence of HAV markers in a cohort of HIV-infected patients from 1988 to 2004. The presence of serum anti-HAV antibodies and HAV-RNA by real-time polymerase chain reaction was investigated in 581 patients. Total anti-HAV antibodies was found in 464/581 (79.8%) patients, however, achanging epidemiologic pattern of hepatitis A among HIV-infected patients from 1988 to 2004 was observed. Among patients susceptible to HAV ( n = 117), 5 (4.2%) were co-infected with HAV, all of them had IgM anti-HAV antibodies and were serum HAV-RNA-positive. The high prevalence of anti-HAV antibodies in HIV-infected patients suggests that screening tests for anti-HAV antibodies should be performed before implementation of hepatitis A vaccination, especially in those patients from endemic countries.

Publisher

SAGE Publications

Subject

Infectious Diseases,Pharmacology (medical),Public Health, Environmental and Occupational Health,Dermatology

Link

http://journals.sagepub.com/doi/pdf/10.1258/ijsa.2007.007100

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