A case study of delayed HIV-1 seroconversion highlights the need for Combo assays-Reference-Cited by-同舟云学术

A case study of delayed HIV-1 seroconversion highlights the need for Combo assays

Published:2009-03 Issue:3 Volume:20 Page:205-206
ISSN:0956-4624
Container-title:International Journal of STD & AIDS
language:en
Short-container-title:Int J STD AIDS

Author:

Skidmore S¹,Devendra S²,Weaver J²,Short J³,Osman H⁴,Smit E⁴

Affiliation:

1. Department of Microbiology, Shrewsbury and Telford Hospital NHS Trust, Telford TF1 6TF

2. Department of Genito-urinary Medicine, Telford and Wrekin NHS PCT, Telford TF1 6TF

3. Department of Sexual Health, Heartlands Hospital, Birmingham B9 5SS

4. Health Protection Agency Public Health Laboratory, Heartlands Hospital, Birmingham B9 5SS, UK

Abstract

Summary This report describes a case in which a patient took at least four months to seroconvert to anti-HIV positivity. A concomitant CMV infection probably contributed to the profound immune suppression observed. It is essential that fourth generation HIV antigen/antibody combo assays be used to ensure that such cases are not missed.

Publisher

SAGE Publications

Subject

Infectious Diseases,Pharmacology (medical),Public Health, Environmental and Occupational Health,Dermatology

Link

http://journals.sagepub.com/doi/pdf/10.1258/ijsa.2008.008263

Reference7 articles.

1. Reappearance of HIV antibody in an infected, seronegative individual after treatment with highly active antiretroviral therapy

2. False-negative HIV antibody test results

3. Simultaneous Transmission of Human Immunodeficiency Virus and Hepatitis C Virus from a Needle-Stick Injury

4. Temporal relation of antigenaemia and loss of antibodies to core antigens to development of clinical disease in HIV infection.

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A case of HIV-1 slow seroconversion: diagnostic implications;International Journal of STD & AIDS;2013-02

2. The Implementation and Appraisal of a Novel Confirmatory HIV-1 Testing Algorithm in the Microbicides Development Programme 301 Trial (MDP301);PLoS ONE;2012-09-11

3. Current concepts in serological testing - TTID;ISBT Science Series;2011-05-13

4. Performance evaluation of the ADVIA Centaur® HIV Ag/Ab Combo assay;Journal of Virological Methods;2010-12

5. Immunoassays for the diagnosis of HIV: meeting future needs by enhancing the quality of testing;Future Microbiology;2009-10