Comparative Experimental Biomodelling of NSAID-induced Enterocolitis-Reference-Cited by-同舟云学术

Comparative Experimental Biomodelling of NSAID-induced Enterocolitis

Published:2020-02-28 Issue:1 Volume:16 Page:65-81
ISSN:2074-5982
Container-title:Journal Biomed
language:
Short-container-title:BIOMEDICINE

Author:

Klesov R. A.¹,Karkischenko V. N.¹,Stepanova O. I.¹,Baranova O. V.²

Affiliation:

1. Scientiﬁc Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia

2. Treatment and Rehabilitation Center of the Ministry of Healthcare of the Russian Federation

Abstract

Use of non-steroidal anti-inﬂammatory drugs (NSAIDs) is considered to be a factor in the development of gastrointestinal tract (GIT) diseases. Thus, enterocolitis is a frequent complication of NSAIDs. Experimental modelling of GIT diseases in laboratory animals, which describes the origin and mechanism of the corresponding disease in humans with maximal precision, is an urgent problem of modern medicine. This paper presents the results of comparative experimental biomodelling of NSAID-induced enterocolitis in laboratory rats. It was found that the intragastric administration of acetylsalicylic acid resulted mainly in stomach damage. The introduction of dexketoprofen — both orally and intramuscularly — causes erosive and ulcerative lesions of the stomach and intestines. The type of damage showed no correlation with the type of administration. For the ﬁrst time, the results of enterocolitis biomodelling using dexketoprofen are presented.

Publisher

Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency

Subject

General Medicine

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