Antimicrobial Peptides Based on Bacterial S1 Protein Sequences as a Potential Alternative to Antibiotics-Reference-Cited by-同舟云学术

Antimicrobial Peptides Based on Bacterial S1 Protein Sequences as a Potential Alternative to Antibiotics

Published:2022-10-17 Issue:3 Volume:18 Page:84-89
ISSN:2713-0428
Container-title:Journal Biomed
language:
Short-container-title:BIOMEDICINE

Author:

Galzitskaya O. V.¹,Machulin A. V.²,Deryusheva E. I.³,Glyakina A. V.⁴,Grishin S. Yu.⁵,Kurpe S. R.⁵,Panfilov A. V.⁵,Domnin P. A.⁶,Kravchenko S. V.⁷,Ermolaeva S. A.⁸

Affiliation:

1. Institute of Protein Research of the Russian Academy of Sciences; Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences

2. Skryabin Institute of Biochemistry and Physiology of Microorganisms of the Russian Academy of Sciences

3. Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences”

4. Institute of Protein Research of the Russian Academy of Sciences; Institute of Mathematical Problems of Biology of the Russian Academy of Sciences — Branch of “Federal Research Center Institute of Applied Mathematics named after M.V. Keldysh of the Russian Academy of Sciences”

5. Institute of Protein Research of the Russian Academy of Sciences

6. National Research Center of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health Care of Russia; Lomonosov Moscow State University

7. Institute of Environmental and Agricultural Biology (X-BIO), Tyumen State University

8. National Research Center of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health Care of Russia

Abstract

An original approach to the development of antimicrobial peptides (AMPs) with a new mechanism of action based on directed coaggregation of a peptide with a target protein is proposed. The unique multifunctional bacterial ribosomal protein S1 was chosen as the target protein. The amyloidogenic and antibacterial effects of various peptides synthesized on the basis of S1 ribosomal protein sequences were studied. The results obtained can serve as a basis for the creation of new AMPs against various strains of pathogenic organisms.

Publisher

Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency

Subject

General Medicine

Reference13 articles.

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