Effects of L-Ornithine L-Aspartate on the Physical Performance with Experimental Non-Alcoholic Fatty Liver Disease

Author:

Prikhodko V. A.1,Poveryaeva M. A.1,Sysoev Yu. I.1,Shustov E. B.1,Bunyat A. V.1

Affiliation:

1. Saint Petersburg State Chemical Pharmaceutical University of the Ministry of Health Care of Russia

Abstract

In the present study, we evaluated the effects of L-ornithine L-aspartate on the physical performance of C57BL/6 mice with experimental non-alcoholic fatty liver disease (NAFLD) induced by a high-caloric “western” diet combined with intraperitoneal carbon tetrachloride injections. Using the forced swim test and triple weight-loaded exhaustive swim test, this model of NAFLD was shown to cause a significant impairment of physical performance and a decrease in physical recovery. L-ornithine L-aspartate was found to significantly improve physical performance and benefit post-exercise recovery in mice with NAFLD.

Publisher

Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency

Subject

General Medicine

Reference4 articles.

1. Dudarenko S.V., Kovalenko A.L., Prokopenko S.M., Belogurova E.V. Primenenie remaksola v terapii metabolicheskogo sindroma u patsientov s nealkogol’nym steatogepatitom i sakharnym diabetom 2 tipa [The use of remaxol in the treatment of metabolic syndrome in patients with nonalcoholic steatohepatitis and diabetes mellitus 2 type]. Eksperimental’naia i klinicheskaia gastroenterologiia [Experimental & clinical gastroenterology]. 2016;130(6):89–94. (In Russian).

2. Karkischenko N.N., Karkischenko V.N., Shustov E.B., Berzin I.A., Kapanadze G.D., Fokin Yu.V., et al. Biomeditsinskoe (doklinicheskoe) izuchenie lekarstvennykh sredstv, vliyayushchikh na fizicheskuyu rabotosposobnost’: Metod. rekom. [Biomedical (preclinical) studies of drugs modulating physical performance. Мethodological recommendations]. Moscow: Federal Medical and Biological Agency Publ., 2017. 134 p. (In Russian).

3. Moretti R., Caruso P., Gazzin S. Non-alcoholic fatty liver disease and neurological defects. Ann. Hepatol. 2019;18(4):563–570. DOI: 10.1016/j.aohep.2019.04.007.

4. Tsuchida T., Lee Y.A., Fujiwara N., et al. A simple dietand chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer. J. Hepatol. 2018;69(2):385–395. DOI: 10.1016/j.jhep.2018.03.011.

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