Affiliation:
1. Izhevsk State Medical Academy of the Ministry of Health care of Russia
Abstract
Under the conditions of a chronic methionine diet (daily addition of amino acids to food (0.15 g/100 g) and water (1% solution)) during 2–12 weeks, the dynamics of liver tests, infl ammatory changes in the blood and blood lipids was monitored. It was found that a methionine diet (MD) leads, starting from 4 weeks of MD, to medium hyperhomocysteinemia, an increase in liver enzymes (AsAT – 1.73, AlAT – 1.5 times, p<0.05) and bilirubin (by 62.25%), which indicates the formed hepatopathy. Further (12 weeks of MD), the condition is aggravated by an abnormality of excretory liver function and the development of cholestasis (an increase in alkaline phosphatase by 1.65, bilirubin – by 3.31 times, p<0.05).
Publisher
Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency
Reference32 articles.
1. Karkischenko N.N. Klassicheskie i al’ternativny’e modeli v lekarstvennoj toksikologii [Classical and alternative models in drug toxicology]. Biomeditsina [Journal Biomed.]. 2006;4:1–23. (In Russian).
2. Medvedev D.V., Zvyagina V.I., Fomina M.A. Sposob modelirovaniya tyazheloj formy gipergomocisteinemii u krys [A method of modeling a severe form of hyperhomocysteinemia in rats]. Rossijskij mediko-biologicheskij vestnik im. akad. I.P. Pavlova [I.P. Pavlov Russian Medical Biolodical Herald]. 2014;22(4):42– 46. (In Russian).
3. Novogrodskaya Ya.I., Kravchuk R.I., Ostrovskaya O.B., Kurbat M.N. Morfologicheskie izmeneniya v pecheni kry’s pri gipergomocisteinemii [Morphological changes in the rat liver in hyperhomocysteinemia]. Hepatology and gastroenterology. 2019;3(1):93–98. (In Russian)].
4. Panteleev K.E., Pazinenko K.A., Pazinenko O.A. Metionin-inducirovannaya toksicheskaya gepatopatiya [Methionine-induced toxic hepatopathy]. Universitetskaya medicina Urala [University medicine of the Urals]. 2020;6(1):21–22. (In Russian)].
5. Smirnov A.V., Dobronravov V.A., Nevrotin A.I., Xoxlov S.E., Sipovskij V.G., Barabanova V.V., Chefu S.G., Zhloba A.A., Blashko E’.L. Gipergomocisteinemiya usugublyaet povrezhdeniya nefrona pri e’ksperimental’noj xronicheskoj pochechnoj nedostatochnosti [Hyperhomocysteinemia exacerbates damage to the nephron in experimental chronic kidney failure]. Nephrology. 2005;9(4):67–74. (In Russian)].