Affiliation:
1. Lomonosov Moscow State University
2. Rostov State Medical University of the Ministry of Health care of Russia
Abstract
This review analyzed the literature data on the in vitro preclinical study of the cytotoxic properties of organotin compounds, as well as the main mechanisms of their action. The latter consist in interacting with SH groups of proteins, initiating oxidative stress, binding to DNA, interacting with receptors, as well as activate apoptosis by increasing the expression of caspases, proapoptotic proteins, and decreasing antiapoptotic proteins. Organotin compounds, depending on the donor ligand, exhibit specifi c cytotoxicity towards certain tumor cell lines. The high cytotoxic potential indicates the possibility of further development in vivo and research of organotin compounds as candidates for the creation of drugs for anticancer and antimetastatic therapy.
Publisher
Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency
Reference38 articles.
1. Zueva E.P., Razina T.G., Amosova E.N., Lopatina K.A., Rybalkina O.Yu., Safonova E.A. Skriningovye issledovaniya na zhivotnyh v onkofarmakologii: pravo na sushchestvovanie [Screening studies on animals in oncopharmacology: the right to exist]. Information technologies in medicine, biology, pharmacology and ecology: materials of Information technologies in medicine, biology, pharmacology and ecology: materials of the International conference. 2018:121–125. (In Russian)].
2. Mukhatova E.M., Osipova V.P., Kolyada M.N., Movchan N.O., Shpakovsky D.B., Gracheva Yu.A., Orlova S.I., Milaeva E.R. Sintez i antioksidantnaya aktivnost’ novykh olovoorganicheskikh soyedineniy, soderzhashchikh fragment 2,6-di-tret-butilfenola [Synthesis and antioxidant activity of new organotin compounds excites the 2,6-di-tret-butylphenol fragment]. Doklady Akademii nauk [Reports of the Academy of Sciences]. 2013;451(1):46–49. (In Russian)]. DOI: 10.7868/S0869565213190134.
3. Alama A., Tasso B., Novelli F., Sparatore F. Organometallic compounds in oncology: Implications of novel organotins as antitumor agents. Drug Discov. Today. 2009;14:500–508. DOI: 10.1016/j. drudis.2009.02.002.
4. Antonenko T.A., Shpakovsky D.B., Berseneva D.А., Gracheva Yu A., Dubova L.G., Shevtsov P.N., Redkozubova O.M., Shevtsova E.F., Tafeenko V.A., Aslanov L.A., Milaeva E.R. Cytotoxic activity of organotin carboxylates based on synthetic phenolic antioxidants and polycyclic bile acids. J. Organomet. Chem. 2020;909:121089. DOI: 10.1016/j.jorganchem.2019.121089.
5. Antonenko T.A., Shpakovsky D.B., Vorobyov M.A., Gracheva Yu A., Kharitonashvili E.V., Dubova L.G., Shev tsova E.F., Tafeenko V.A., Aslanov L.A., Iksanova A.G., Shtyrlin Yu.G., Milaeva E.R. Antioxidative vs cytotoxic activities of organotin complexes bearing 2,6-di-tert-butylphenol moieties. Appl. Organomet. Chem. 2018;32(7):e4381. DOI: 10.1002/aoc.4381.
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