Osteogenesis and Histostructure of Femoral Muscles When Modeling a Femoral Fracture with Immediate or Delayed Osteosynthesis Using an Interlocking Intramedullary Antegrade Rod-Reference-Cited by-同舟云学术

Osteogenesis and Histostructure of Femoral Muscles When Modeling a Femoral Fracture with Immediate or Delayed Osteosynthesis Using an Interlocking Intramedullary Antegrade Rod

Published:2020-06-10 Issue:2 Volume: Page:78-88
ISSN:2074-5982
Container-title:Journal Biomed
language:
Short-container-title:BIOMEDICINE

Author:

Filimonova G. N.¹,Antonov N. I.¹,Emanov A. A.¹

Affiliation:

1. Russian Scientifi c Center “Reconstructive Traumatology and Orthopedics” Named after Academician G.A. Ilizarov of the Ministry of Health Care of Russia

Abstract

Interlocked intramedullary osteosynthesis is the most common method for treating femoral shaft fractures. The aim — to reveal specifi c characteristics of the histostructure of canine femoral muscles when healing femoral fractures under osteosynthesis using interlocking intramedullary reinforcement with an antegrade metal rod. Femoral shaft fractures were modelled in 9 mongrel dogs. The fractures were fi xed with an intramedullary rod. In Group I (n=4), osteosynthesis was started immediately after bone injury. In Group II (n=5), osteosynthesis was started 4 days after fracture (delayed osteosynthesis). M. biceps femoris and M. quadriceps femoris were studied. In Group I and Group II, bone healing occurred following 42 and 70 days, respectively. A unifi ed bone marrow cavity and cortical layer had been formed by day 70 and day 100 in Group I and Group II, respectively. The histostructure of M. quadriceps femoris in Group I remained largely unchanged throughout the experiment, while M. biceps femoris underwent the process of structural reorganization on days 42 and 70 of the experiment. The Group of delayed osteosynthesis demonstrated changes in the histostructure of both muscles, including an increased diversity of fi bre diameters, an increased number of nuclei in myocytes, fi brosis of the interstitial space and perimysial arterial vessels. These changes were more pronounced in M. biceps femoris. Three months after injury, the histostructure of the muscles under study, even in the Group of delayed osteosynthesis, had no signifi cant differences and tended to the intact norm. In femoral fractures, the earliest possible fi xation of bone fragments with an inter locking antegrade intramedullary rod is recommended. A complete bone healing in such cases occurs a month earlier than in those with delayed osteosynthesis. The femoral muscles of the anterior group are injured to a lesser extent than those of the posterior group.

Publisher

Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency

Subject

General Medicine

Reference24 articles.

1. Azizov M.Zh., Dursunov A.M., Abdulkhakov N.T., Saidiakhmatkhonov S.S. Blo kiruyushchiy intramedullyarnyy osteosintez pri diafi zarnykh perelomakh dlinnykh kostey [Interlocking intramedullary osteosynthesis for shaft fractures of long bones]. Vestnik ekstrennoy meditsiny [Herald of Emergency Medicine]. 2011;(4):38–42. (In Russian).

2. Antoniadi Yu.V., Chernitsin D.N., Zhiryakov D.L., Mukmenov M.M., Zhuravlev A.A., Zverev F.N. Zakrytyy intramedullyarnyy osteosintez v lechenii perelomov kostey nizhney konechnosti v usloviyakh gorodskoy bolnitsy [Closed intramedullary osteosynthesis in the treatment of fractures of the lower limb bones in a city hospital]. In: Mat-ly Vseross. nauchno-prakt. konf. “Ilizarovskie chte niya” [Materials of All-Russian Scientifi cPractical Conference “Ilizarov Readings”]. Kurgan, 2010. P. 30–31. (In Russian).

3. Barabash A.P., Barabash A.Yu., Zuev P.P. Doklinicheskoe issledovanie nadezhnosti intramedullyarnykh sterzhney dlya osteosinteza u patsientov s oskolchatymi perelomami diafi za bedrennoy kosti cheloveka [Preclinial study of the reliability of intramedullary rods for osteosynthesis in patients with human comminuted femoral shaft fractures]. Vestnik Dagestanskoj gosudarstvennoj medicinskoj akademii [Herald of Dagestan State Medical Academy]. 2016;18(1):42–49. (In Russian).

4. Dergachev V.V., Aleksandrov A.N., Vankhalskiy S.B., Onatskiy Yu.V., Kotenko R.S., Kolesnikov A.M. Intramedullyarnyy blokiruyushchiy osteosintez — sovremennaya metodika, novye slozhnosti, oslozhneniya [Intramedullary interlocking osteosynthesis — modern technique, new diffi culties, complications]. Trauma. 2011;12(4):20– 23. (In Russian).

5. Emanov A.A., Gorbach E.N., Antonov N.I., Martel I.I. Osobennosti osteogeneza pri lechenii diafi zarnykh perelomov bedrennoy kosti v zavisimosti ot tyazhesti travmy (eksperimental’noe issledovanie) [Osteogenesis characteristics in the treatment of femoral shaft fractures depending on injury severity (An experimental study)]. Aktual’nye voprosy veterinarnoy biologii [Actual Problems of Veterinary Biology]. 2013;19(3):72–77. (In Russian).