RABBIT BIOMODELS OF HUMAN DISEASES DEVELOPED USING NEW GENOMIC TECHNOLOGIES. CRISPR/CAS9 (REVIEW)

Author:

Koloskova E. M.1,Karkischenko V. N.2,Yezersky V. A.1,Petrova N. V.2,Maksimenko S. V.2,Matveyenko E. L.2

Affiliation:

1. All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition — branch of the Federal Scientific Center of Animal Husbandry — The All-Russian Institute of Animal Husbandry named after academician L.K. Ernst

2. Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia

Abstract

With the advent of endonuclease methods of genome editing, particularly CRISPR/Cas9, it has become possible to obtain genetically modified rabbits by microinjection of zygotes. These highly effective human disease models can be used for various purposes. The present review aims to consider modern achievements in the creation of rabbit biomodels of human diseases using the technologies of genetic editing. It is concluded that Russian laboratories should intensify research in the development of genetically modified rabbits that can be used for various biomedical studies and biomodelling.

Publisher

Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency

Subject

General Medicine

Reference100 articles.

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1. Monoclonal antibody techniques. 50 years of development;Journal of microbiology, epidemiology and immunobiology;2024-07-16

2. Conflict of interest: the authors declare no conflict of interest.;Journal Biomed;2021-02-25

3. Using CRISPR/Cas9 technology to create genetically modified rabbits;Journal of Livestock Science;2021-01-03

4. Genetically modified rabbits as bio-producers and biomodels;E3S Web of Conferences;2020

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