Pharmacological Screening of Cholinergic Drugs Using <i>Daphnia magna Straus</i> Hydrobionts as a Biological Test Object-Reference-Cited by-同舟云学术

Pharmacological Screening of Cholinergic Drugs Using <i>Daphnia magna Straus</i> Hydrobionts as a Biological Test Object

Published:2024-04-05 Issue:1 Volume:20 Page:43-51
ISSN:2713-0428
Container-title:Journal Biomed
language:
Short-container-title:BIOMEDICINE

Author:

Bondarenko A. A.¹,Gorchakova T. L.²,Bespalov A. Ya.²,Prokopenko L. I.²,Shabanov P. D.³

Affiliation:

1. Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia; Institute of Experimental Medicine

2. Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia

3. Institute of Experimental Medicine

Abstract

This work presents the results of primary pharmacological screening of anticholinergic drugs and comparative evaluation of their specific activity in equitoxic concentrations using Daphnia magna Straus hydrobionts as a biological test object. We determine the protective index and the minimum effective concentration in terms of preventing atypical motor hyperactivity of pharmacological substances when poisoning with a reversible acetylcholinesterase inhibitor. On the basis of the results obtained, the list of promising candidates for further research in warm-blooded animals is extended by all of the anticholinergic drugs previously selected in experiments on mammals.

Publisher

Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency

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