Affiliation:
1. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University of the Ministry of Health Care of Russia
2. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
3. Siberian State Medical University of the Ministry of Health Care of Russia
Abstract
Anthocyanins are flavonoid compounds belonging to the group of polyphenols. A. melanocarpa (Michx.) Elliott chokeberry is known to be rich in these bioactive substances. The previously conducted chemical analysis showed that an anthocyanin-containing complex obtained from A. melanocarpa fruits comprise anthocyanins, flavonoids, phenolic acids, and catechins, with anthocyanins being the dominant components. A large amount of data indicates that Aronia fruits exhibit a wide spectrum of pharmacological activity. In this work, we assess the safety of an anthocyanin-containing complex obtained from A. melanocarpa fruits by its genotoxic study followed by an analysis of its effect on mutagenesis. To this end, a model of doxorubicin-induced genotoxicity in bone marrow cells of C57Bl/6 mice was used. The plant complex under study at a dose of 225 mg/kg had no effect the cytogenetic parameters of animal bone marrow cells after a single or double administration. The use of the anthocyanin-containing complex led to a decrease in DNA damage caused by the administration of doxorubicin, 24 and 48 hours after the introduction of a cytostatic agent. Hence, the data obtained can serve as the basis for the creation of a drug corrector for cycplasms.
Publisher
Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency
Reference25 articles.
1. Andreeva V.Yu., Kalinkina G.I., Kolomiec N.E., Isajkina N.V. Metodika opredeleniya antocianov v plodah aronii chernoplodnoj. [Method for the determination of anthocyanins in the fruits of black chokeberry]. Pharmacy. 2013;3:19–21. (In Russian).
2. Andreyeva V.Yu., Sheykin V.V., Kalinkina G.I., Razina T.G., Zuyeva Ye.P., Rybalkina O.Yu., Ul'rikh A.V. Razrabotka sredstva na osnove plodov aronii chernoplodnoj (Arónia melanocárpa (Michx.) Elliot), povyshayushchego effektivnost' himioterapii opuholej [Development of a drug based on the fruits of chokeberry (Arónia melanocárpa (Michx.) Elliot), which increases the effectiveness of tumor chemotherapy]. Khimiya rastitel'nogo syr'ya [Chemistry of plant materials]. 2020;4:219–226. (In Russian). DOI: 10.14258/jcprm.2020046339.
3. Goncharova R.I., Dalivelya O.V., Kuzhir T.D. Klastogennost' etilmetansul'fonata i dimetiltereftalata v mikroyadernom teste i puti ee modifikacii [Clastogenicity of ethyl methanesulfonate and dimethyl terephthalate in the micronucleus test and ways of its modification]. Cytology and genetics. 2002;36(1):14–25. (In Russian).
4. Gosudarstvennyj reestr lekarstvennyh sredstv: nauch. izdanie [State Pharmacopoeia of the Russian Federation: scientific publication]. Moscow: Minzdrav Rossii. 2020:1006. (In Russian).
5. Gosudarstvennaya Farmakopeya Rossijskoj Federacii: nauch. izdanie [State Pharmacopoeia of the Russian Federation: scientific publication]. Moscow: Minzdrav Rossii. 2007:684. (In Russian).