Experimental Model to Substantiate the Application of New Biologically Active Substances for Correcting Physiological Processes and Functions

Author:

Erimbetov K. T.1,Zemlyanoy R. A.1,Fedorova A. V.2,Obvintseva O. V.3

Affiliation:

1. Research Technological Center “Preventive Information Medicine”

2. Medical Radiological Research Center named after A.F. Tsyb — Branch of the National Medical Research Center for Radiology of the Ministry of Health Care of Russia

3. All-Russian Research Institute of Physiology, Biochemistry and Nutrition of Animals — Branch of the Federal Research Center for Animal Husbandry — All-Russian Institute of Animal Husbandry named after L.K. Ernst

Abstract

In this research, we aim to develop and investigate nanostructured clathrate complexes of 20-hydroxyecdysterone, a rhodanine derivative of 3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one, with various clathrate formers, such as arabinogalactan and β-cyclodextrin. For the first time, an experimental model is proposed to justify their use for the correction of physiological processes and functions, both in normal and pathologic conditions in the animal body. The results obtained substantiate the possibility of regulating metabolic processes by activating signaling pathways associated with cell proliferation.

Publisher

Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency

Subject

General Medicine

Reference6 articles.

1. Erimbetov K.T., Obvintseva O.V., Solov'eva A.G., Fedorova A.V., Zemlyanoi R.A. Signal'nye puti i faktory regulyatsii sinteza i raspada belkov v skeletnykh myshtsakh (obzor). Problemy biologii produktivnykh zhivotnykh. 2020;1:24–33. [Erimbetov K.T., Obvintseva O.V., Solovieva A.G., Fedorova A.V., Zemlyanoy R.A. Signal'nye puti i faktory regulyatsii sinteza i raspada belkov v skeletnykh myshtsakh (obzor) [Signaling pathways and factors regulating the synthesis and breakdown of proteins in skeletal muscles (review)]. Problemy biologii produktivnykh zhivotnykh [Problems of productive animals biology]. 2020;1:24–33. (In Russian)]. DOI: 10.25687/1996-6733.prodanimbiol.2020.1.24-33.

2. Anthony T.G. Mechanisms of protein balance in skeletal muscle. Domest. Anim. Endocrinol. 2016;56(Suppl.): 23–32. DOI: 10.1016/j.domaniend. 2016.02.012.

3. Davis T.A., Fiorotto M.L., Suryawan A. Bolus vs. continuous feeding to optimize anabolism in neonates. Curr. Opin. Clin. Nutr. Metabol. Care. 2015;18(1):102– 108. DOI: 10.1097/MCO.0000000000000128.

4. Davis T.A., Suryawan A., Orellana R.A., Fiorotto M.L., Burrin D.G. Amino acids and insulin are regulators of muscle protein synthesis in neonatal pigs. Animal. 2010;4(11):1790–1796. DOI: 10.1017/ S1751731110000984.

5. Davis T.A., Suryawan A., Orellana R.A., Nguyen H.V., Fiorotto M.L. Postnatal ontogeny of skeletal muscle protein synthesis in pigs. J. Anim. Sci. 2008;86(14 Suppl.):13–18. DOI: 10.2527/jas.2007-0419.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3