S-Protein of the Probiotic Strain Lactobacillus crispatus 2029 Prevents the Growth of Permeability of the Caco-2 Monolayer of Human Enterocytes Induced by Intestinal Infections

Author:

Kosarev I. V.1,Vasilenko R. N.1,Abramov V. M.1,Sakulin V. K.1,Khlebnikov V. S.1,Pchelintsev S. Yu.1,Machulin A. V.2,Abashina T. N.2,Samoilenko V. A.2,Uversky V. N.3,Karlyshev A. V.4

Affiliation:

1. Institute of Immunological Engineering

2. Federal Research Center “Pushchino Scientifi c Center for Biological Research of the Russian Academy of Sciences”

3. University of South Florida

4. Kingston University London

Abstract

The use of a biomodel of the confluent monolayer Caco-2 of enterocytes allowed us to reveal the ability of the S-protein isolated from strain LC2029 to prevent permeability disorders resulting from intestinal infections induced by pathogens (E. coli O157: H7, C. jejuni ATCC 33291, S. enteritidis ATCC 25928). This is important for maintaining the efficiency of the intestinal barrier.

Publisher

Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency

Subject

General Medicine

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