Affiliation:
1. Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Abstract
A study of different modes of administration of bioactive substances (BAS) of algae F. vesiculosus and S. latissima to laboratory animals allowed the authors to establish the doses and duration of administration, at which the complexes under study show moderate cytoprotective activity (15 and 30 mg/kg for S. latissima, 60 and 120 mg/kg for F. vesiculosus; three-day administration). It was found that the complex of BAS F. vesiculosus is characterized by a higher activity with respect to erythrocyte osmotic resistance compared to the complex of BAS S. latissima. At the same time, the complex of BAS laminaria is characterized by a higher activity with respect to erythrocyte peroxide resistance. The above features emphasize the feasibility of combined use of these extracts. At three-day combined administration of complexes of BAS F. vesiculosus and S. latissima at doses of 60 and 15 mg/kg, respectively, their high membrane-protective and antioxidant activity was determined. However, a higher dose or longer administration of the BAS complexes negatively affects the resistance of erythrocyte membranes.
Publisher
Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency
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