Affiliation:
1. Zakusov Institute of Pharmacology
Abstract
We studied the pharmacokinetics of a drug preparation, ethyl ester of N-phenylacetyl-glycyl-L-proline, exhibiting neuroprotective activity and its metabolite cyclo-L-prolylglycine in rat blood plasma after a single intravenous administration at a dose of 20 mg/kg. The metabolite was found to circulate in the systemic bloodstream of animals twice as long as the ethyl ester of N-phenylacetyl-glycyl-L-proline, with its plasma concentrations being 50–70 times higher than those of the parent compound.
Publisher
Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency
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