Affiliation:
1. N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Сare Department
2. N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Сare Department;
Moscow Aviation Institute (National Research University)
Abstract
On a sample of 14 rats, the role of cholinergic mechanisms in the effects of GABA on the small bowel electrical activity under the conditions of 18-hour food deprivation in a chronic experiment was studied. Administration of GABA at a dose of 70 mg/kg resulted in stimulation of phase II (irregular activity) and the disappearance of phases I (rest) and III (regular activity) of the migrating myoelectric complex (MMC). The main effect of the M-cholinoblockator — atropine (1 mg/kg) was manifested in the disappearance of phase III MMC. The administration of GABA after the administration of atropine caused the appearance of extraordinary phase III MMC, thereby exerting a release effect on the regular (propulsive) activity of the small intestine. Therefore, one of the mechanisms of GABA action on the electrical activity of the small intestine is cholinergic pathways.
Publisher
Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency