Efficacy of High Doses of Protons on the Induction of Solid Tumors in Mice by <i>Ex vivo</i> Irradiation of Ehrlich Ascitic Carcinoma Cells-Reference-Cited by-同舟云学术

Efficacy of High Doses of Protons on the Induction of Solid Tumors in Mice by <i>Ex vivo</i> Irradiation of Ehrlich Ascitic Carcinoma Cells

Published:2023-11-20 Issue:3E Volume:19 Page:66-70
ISSN:2713-0428
Container-title:Journal Biomed
language:
Short-container-title:BIOMEDICINE

Author:

Strelnikova N. S.¹,Rozanova O. M.²,Smirnova H. N.²,Belyakova T. A.¹,Smirnov A. V.¹

Affiliation:

1. Branch “Physical Technical Center”, P.N. Lebedev Physical Institute of the Russian Academy of Sciences

2. Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences

Abstract

We study the induction patterns of the solid form of Ehrlich ascitic carcinoma (EAC) in mice in the short(1 month) and long-term (18 months) periods after inoculation of ascitic cells irradiated ex vivo with a proton beam at doses of 30, 60, 90, 120, and 150 Gr. The growth rate of solid tumors after inoculation of irradiated cells ex vivo coincided with the growth of tumors in the control group. The frequency of tumor induction in mice transplanted with EAC cells was dose-dependent and decreased from 80% to 0% along with an increase in radiation dose. Thus, using the ex vivo model of tumor cell irradiation followed by in vivo grafting allowed us to determine the parameters of the antitumor effect of new proton therapy regimens.

Publisher

Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency

Subject

General Medicine

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