Effect of L-thyroxine, a Human Serum Albumin Natural Ligand, on the Kinetics of β-amyloid Peptide Fibril Formation-Reference-Cited by-同舟云学术

Effect of L-thyroxine, a Human Serum Albumin Natural Ligand, on the Kinetics of β-amyloid Peptide Fibril Formation

Published:2023-11-21 Issue:3E Volume:19 Page:114-118
ISSN:2713-0428
Container-title:Journal Biomed
language:
Short-container-title:BIOMEDICINE

Author:

Litus E. A.¹,Nemashkalova E. L.¹,Vologzhannikova A. A.¹,Deryusheva E. I.¹

Affiliation:

1. Institute for Biological Instrumentation of the Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences

Abstract

Ligands of human serum albumin (HSA) are capable of modulating its interaction with β-amyloid peptide (Aβ), which is a key factor in the pathogenesis of Alzheimer’s disease (AD). L-thyroxine (L-Tr), a natural HSA ligand, is associated with the pathogenesis of AD according to epidemiological and animal model studies. In this work, we studied the kinetics of Aβ fibril formation in the presence of L-Tr and HSA using a fluorescent test with thioflavin T. L-Tr had no significant effect on the inhibitory effect of HSA on fibril growth. At the same time, L-Tr itself had an inhibitory effect similar to that of HSA. Our data can partially explain the relationship between AD and thyroid pathologies.

Publisher

Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency

Subject

General Medicine

Reference12 articles.

1. Deryusheva E.I., Nemashkalova E.L., Shevelyova M.P., Litus E.A. Bioinformaticheskij poisk i formirovanie paneli ligandov syvorotochnogo al'bumina, moduliruyushchih ego vzaimodejstvie s Aβpeptidom [Bioinformatic search and formation of a panel of serum albumin ligands that modulate its interaction with Aβ-peptide]. Dokl. Mezhd. konf. “Matematicheskaya biologiya i bioinformatika” [Proceedings of the International Conference “Mathematical Biology and Bioinformatics”]. Ed. by V.D. Lakhno. Vol. 9. Pushchino: IMBP of the RAS Publ., 2022. (In Russian). DOI: 10.17537/icmbb22.1.

2. Cheng S.Y., Leonard J.L., Davis P.J. Molecular aspects of thyroid hormone actions. Endocr. Rev. 2010;31(2):139–170. DOI: 10.1210/er.2009-0007.

3. Fu A.L., Zhou C.Y., Chen X. Thyroid hormone prevents cognitive deficit in a mouse model of Alzheimer's disease. Neuropharmacology. 2010;58(4–5):722–729. DOI: 10.1016/j.neuropharm.2009.12.020.

4. Choi T.S., Lee H.J., Han J.Y., Lim M.H., Kim H.I. Molecular insights into human serum albumin as a receptor of amyloid-β in the extracellular region. J. Am. Chem. Soc. 2017;139(43):15437–15445. DOI: 10.1021/jacs.7b08584.

5. Ishima Y., Mimono A., Tuan Giam Chuang V., Fukuda T., Kusumoto K., Okuhira K., Suwa Y., Watanabe H., Ishida T., Morioka H., Maruyama T., Otagiri M. Albumin domain mutants with enhanced Aβ binding capacity identified by phage display analysis for application in various peripheral Aβ elimination approaches of Alzheimer's disease treatment. IUBMB Life. 2020;72(4):641–651. DOI: 10.1002/iub.2203.