Evaluation of Platelet Indexes of HBsAg Positive Patients

Abstract

OBJECTIVE: Hepatitis B virus is the most important cause of chronic liver inflammation. Studies showing that platelets have important functions as an inflammatory trigger in cases of chronic inflammation have increased in recent years. Expressed as platelet (PLT) indices; platelet volume (MPV), platelet distribution width (PDW), and platelet percentage (PCT) values; it is one of the important markers that provide information about the function and activation of platelets. In this study, in HBsAg positive and HBsAg negative patients, it is aimed to evaluate the parameters of PLT, MPV, PDW and PCT. MATERIALS AND METHODS: In this retrospective study, the results of 193 HBsAg positive and 193 HBsAg negative patients who applied to Infectious Diseases Outpatient Clinic of Uşak University Faculty of Medicine Training and Research Hospital were evaluated. The values of PLT, PDW, PCT and MPV parameters were determined using a hemogram device. Student t-test and one- way ANOVA test were used for comparison between the groups. A value of P<0.05 was considered as statistically significant. RESULTS: In our study, while PLT, PDW, PCT and MPV values were determined as 227.36±69.98 103/mm3, 16.34±1.52%, 0.22±0.62% and 9.74±1.10 fl, respectively, in the HBsAg positive patient group, the same values were determined as 224.95±67.48 103/mm3, 16.16±1.08%, 0.22±0.62%, 9.82±1.20 fl, respectively, (p>0.05, p>0.05, p>0.05 and p>0.05, respectively) in the HBsAg negative patient group. In terms of these values, no statistically significant difference was found between the HBsAg positive patient group and the HBsAg negative patient group. In the correlation analysis performed in all cases (n=386), it can be said that there is a very strong negative correlation between PLT and age, MPV, and PDW (respectively, r=-0.156 p=0.06, r=-0.394 p<0.01, r=-0.467 p< 0.01). It was also determined that there was a strong positive correlation (r=0.915 p<0.01) between PLT and PCT. CONCLUSION: In this study, there was no significant difference between HBsAg positive patients and HBsAg negative patients in terms of platelet indices. We recommend that studies on this subject be conducted by grouping hepatitis B patients according to different clinical stages.