Heparin - Pluronic F127 nanogel with optimal component ratio for drug delivery applications

Abstract

This study aimed to synthesize a nanogel system based copolymers of Heparin (Hep) and Pluronic F127 (F127) with optimal Hep:F127 ratio for delivering poor water soluble drug and Platinum-based drugss. Firstly, Hep-F127 conjugates were formed via disulfide bridges of cystamine molecules. The obtained Hep-F127 systems were then proved and characterized using Proton nuclear magnetic resonance (1H-NMR), Dynamic Light Scattering (DLS)) methods. Cisplatin (CPT) was used as the Pt drug model, meanwhile Paclitaxel (PTX) was used as poor water-soluble drug model. The encapsulation ability for CPT and PTX was investigated and compared to choose the optimal Hep-F127 ratio. This Hep-F127 nanogel system is expected to be a good carrier for delivering drugs with different properties.