Synthesis and anti-inflammatory activity evaluation of novel AZT and adenosine derivatives-Reference-Cited by-同舟云学术

Synthesis and anti-inflammatory activity evaluation of novel AZT and adenosine derivatives

Published:2022-12-20 Issue:VITTEP Volume: Page:30-36
ISSN:1859-1043
Container-title:Journal of Military Science and Technology
language:
Short-container-title:JMST

Author:

Le Duc Anh,Doan Thanh Huyen,Vu Van Dung,Hoang Anh Tuan,Pham Quang Thuan,Vu Thanh Dong,Ninh Duc Bao,Vu Tien Luc,Luu Van Chinh,Truong Ngoc Hung

Abstract

A five-step procedure was used to synthesize four novel conjugates of AZT and adenosine with quinazolinone scaffold. In the last step, alkynes-1 of quinazolinone were coupled to adenosine azide and AZT by Click chemistry to yield the designed conjugates. Their structures were characterized by full-length data of spectra including 1H-, 13C-NMR and MS. Screening for their in vitro anti-inflammatory activity was performed using Murine macrophage RAW 264.7 cells. The relationship between structure and biological activity was also discussed.

Publisher

Academy of Military Science and Technology

Reference13 articles.

1. [1]. H. C. Kolb et al, “The growing impact of click chemistry on drug discovery,” Drug Discov. Today. Vol. 8, No. 24, pp. 1128-1137, (2003).

2. [2]. X. Jiang et al, “Recent applications of click chemistry in drug discovery,” Expert Opin. Drug Discov. Vol. 14, No. 8, pp. 779-789, (2019).

3. [3]. Y. W. He et al, “1,2,3-Triazole-containing derivatives of rupestonic acid: click-chemical synthesis and antiviral activities against influenza viruses,” Eur. J. Med. Chem. Vol. 76, pp. 245-255, (2014).

4. [4]. M. F. Mady et al, “Ultrasound-assisted synthesis of novel 1,2,3-triazoles coupled diaryl sulfone moieties by the Cu-AAC reaction, and biological evaluation of them as antioxidant and antimicrobial agents,” Eur. J. Med. Chem. No. 84, pp. 433-443, (2014).

5. [5]. F. J. Pan et al, “Synthesis of 4-phenylthieno[2,3-e][1,2,4]triazolo[4,3-a]pyrimidine-5(4H)-one derivatives and evaluation of their anti-inflammatory activity,” Lett. Drug Des. Discov. Vol. 13, No. 2, pp. 141-148, (2016).