Affiliation:
1. CRTD-Center for Regenerative Therapies Dresden, Technische Universität Dresden , Fetscherstrasse 105, 01307 Dresden , Germany
Abstract
ABSTRACT
Communication between the nervous and immune system is crucial for development, homeostasis and response to injury. Before the onset of neurogenesis, microglia populate the central nervous system, serving as resident immune cells over the course of life. Here, we describe new roles of an uncharacterized transcript upregulated by neurogenic progenitors during mouse corticogenesis: 4931414P19Rik (hereafter named P19). Overexpression of P19 cell-extrinsically inhibited neuronal migration and acted as chemoattractant of microglial cells. Interestingly, effects on neuronal migration were found to result directly from P19 secretion by neural progenitors triggering microglia accumulation within the P19 targeted area. Our findings highlight the crucial role of microglia during brain development and identify P19 as a previously unreported player in the neuro-immune crosstalk.
Funder
Zentrum für Regenerative Therapien Dresden
Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden
Deutsche Forschungsgemeinschaft
Sächsische Landesbibliothek – Staats- und Universitätsbibliothek Dresden
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Cited by
1 articles.
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