Affiliation:
1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
Abstract
The epidermal growth factor receptor (EGFR) signaling cascade represents one of the cardinal pathways that transmits information between cells during development in a broad range of multicellular organisms. Most of the elements that constitute the core EGFR signaling module, as well as a variety of negative and positive modulators, have been identified. Although this molecular pathway is utilized multiple times during development, the spatial and temporal features of its signaling can be modified to fit a particular developmental setting. Recent work has unraveled the various mechanisms by which the EGFR pathway can be modulated.
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
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