JAK/STAT signaling in stem cells and regeneration: from Drosophila to vertebrates-Reference-Cited by-同舟云学术

JAK/STAT signaling in stem cells and regeneration: from Drosophila to vertebrates

Published:2019-01-15 Issue:2 Volume:146 Page:
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Herrera Salvador C.¹,Bach Erika A.¹²^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA

2. Helen L. and Martin S. Kimmel Center for Stem Cell Biology, New York University School of Medicine, New York, NY 10016, USA

Abstract

ABSTRACT The JAK/STAT pathway is a conserved metazoan signaling system that transduces cues from extracellular cytokines into transcriptional changes in the nucleus. JAK/STAT signaling is best known for its roles in immunity. However, recent work has demonstrated that it also regulates critical homeostatic processes in germline and somatic stem cells, as well as regenerative processes in several tissues, including the gonad, intestine and appendages. Here, we provide an overview of JAK/STAT signaling in stem cells and regeneration, focusing on Drosophila and highlighting JAK/STAT pathway functions in proliferation, survival and cell competition that are conserved between Drosophila and vertebrates.

Funder

New York State Stem Cell Science

National Institute of Child Health and Human Development

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/doi/10.1242/dev.167643/1871052/dev167643.pdf

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