Affiliation:
1. National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
Abstract
ABSTRACT
The process of cell competition results in the elimination of cells that are viable but ‘less fit’ than surrounding cells. Given the highly heterogeneous nature of our tissues, it seems increasingly likely that cells are engaged in a ‘survival of the fittest’ battle throughout life. The process has a myriad of positive roles in the organism: it selects against mutant cells in developing tissues, prevents the propagation of oncogenic cells and eliminates damaged cells during ageing. However, ‘super-fit’ cancer cells can exploit cell competition mechanisms to expand and spread. Here, we review the regulation, roles and risks of cell competition in organism development, ageing and disease.
Funder
Medical Research Council
European Molecular Biology Organization
British Heart Foundation
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Cited by
117 articles.
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