Of sex and determination: marking 25 years of Randy, the sex-reversed mouse-Reference-Cited by-同舟云学术

Of sex and determination: marking 25 years of Randy, the sex-reversed mouse

Published:2016-05-15 Issue:10 Volume:143 Page:1633-1637
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Koopman Peter¹^ORCID,Sinclair Andrew²,Lovell-Badge Robin³

Affiliation:

1. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia

2. Murdoch Children's Research Institute and Department of Paediatrics, The University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia

3. The Francis Crick Institute, Mill Hill, London NW7 1AA, UK

Abstract

ABSTRACT On Thursday 9 May 1991, the world awoke to front-page news of a breakthrough in biological research. From Washington to Wollongong, newspapers, radio and TV were abuzz with the story of a transgenic mouse in London called Randy. Why was this mouse so special? The mouse in question was a chromosomal female (XX) made male by the presence of a transgene containing the Y chromosome gene Sry. This sex-reversal provided clear experimental proof that Sry was the elusive mammalian sex-determining gene. Twenty-five years on, we reflect on what this discovery meant for our understanding of how males and females arise and what remains to be understood.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/143/10/1633/1841736/dev137372.pdf

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