Of sex and determination: marking 25 years of Randy, the sex-reversed mouse-Reference-Cited by-同舟云学术

Of sex and determination: marking 25 years of Randy, the sex-reversed mouse

Published:2016-05-15 Issue:10 Volume:143 Page:1633-1637
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Koopman Peter¹^ORCID,Sinclair Andrew²,Lovell-Badge Robin³

Affiliation:

1. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia

2. Murdoch Children's Research Institute and Department of Paediatrics, The University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia

3. The Francis Crick Institute, Mill Hill, London NW7 1AA, UK

Abstract

ABSTRACT On Thursday 9 May 1991, the world awoke to front-page news of a breakthrough in biological research. From Washington to Wollongong, newspapers, radio and TV were abuzz with the story of a transgenic mouse in London called Randy. Why was this mouse so special? The mouse in question was a chromosomal female (XX) made male by the presence of a transgene containing the Y chromosome gene Sry. This sex-reversal provided clear experimental proof that Sry was the elusive mammalian sex-determining gene. Twenty-five years on, we reflect on what this discovery meant for our understanding of how males and females arise and what remains to be understood.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/143/10/1633/1841736/dev137372.pdf

Reference45 articles.

1. Evidence that Sry is expressed in pre-Sertoli cells and Sertoli and Granulosa cells have a common precursor;Albrecht;Dev. Biol.,2001

2. Conceptual frameworks and mouse models for studying sex differences in physiology and disease: why compensation changes the game;Arnold;Exp. Neurol.,2014

3. Genetic evidence equating SRY and the testis-determining factor;Berta;Nature,1990

4. Molecular characterization of three gonad cell lines;Beverdam;Cytogenet. Genome Res.,2003

5. Comparative analysis of anti-mouse SRY antibodies;Bradford;Sex. Dev.,2007

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Sex determination and gonadal differentiation in amphibians;Hormones and Reproduction of Vertebrates, Volume 2;2024

2. Return of the forgotten hero: the role of Y chromosome-encoded Zfy in male reproduction;Molecular Human Reproduction;2023-06-24

3. Towards improved genetic diagnosis of human differences of sex development;Nature Reviews Genetics;2021-06-03

4. Whole-Body Matter;Inflammation and Metastasis;2021

5. Organe des Hormonsystems und ihre Entstehung;Hormone und Hormonsystem - Lehrbuch der Endokrinologie;2020-11-18