Early abrupt recovery from ataxia during vestibular compensation in goldfish

Abstract

1. Vestibular compensation was studied in goldfish that had had the utriculus and semicircular canal organs unilaterally removed. Characteristic postoperative behavioural deficits of postural asymmetry were quantitatively scored. Operated animals were compared with those subject to the same duration of anaesthesia and restraint during a sham operation. 2. The period of several minutes following the operation was characterized by severe postural asymmetry and locomotor ataxia. In the operated fish, but not the sham-operated ones, the eyes rolled tonically towards the operated side without nystagmus, the body was flexed towards the operated side, and any swimming was disoriented with rolling motion towards the operated side. These deficits lasted less than 30 min after revival from the anaesthesia. All three behavioral deficits ended abruptly within 1 min of each other for individual fish, and normal, nearly upright swimming was then maintained, even in the dark. 3. We interpret this recovery as one of the first stages in the central process of vestibular compensation. The unusually abrupt end of these deficits in adult goldfish compared with that in other vertebrates suggests a remarkable capacity for the central nervous system to adapt. The speed of recovery of three distinct motor outputs supports models of early compensation that utilize central modulation or gain control of existing pathways, rather than anatomical reorganization.